GSH-activated MRI-guided enhanced photodynamic- and chemo-combination therapy with a MnO2-coated porphyrin metal organic framework

Xue-Tao Tian; Pei-Pei Cao; Hui Zhang; Yu-Hao Li; Xue-Bo Yin

doi:10.1039/C9CC01957J

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GSH-activated MRI-guided enhanced photodynamic- and chemo-combination therapy with a MnO₂-coated porphyrin metal organic framework†

Xue-Tao Tian,^a Pei-Pei Cao,^b Hui Zhang,^a Yu-Hao Li

^b and Xue-Bo Yin

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Medicinal Chemical, Biology and Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin, China
E-mail: xbyin@nankai.edu.cn

^b Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, School of Medicine, Nankai University, Tianjin, China

Abstract

Glutathione (GSH) in tumors consumes ¹O₂ and seriously inhibits the PDT effect. MnO₂-coated porphyrin metal–organic frameworks are developed to realize the oxidation of GSH by MnO₂ for enhanced PDT, activated MR imaging, and controllable release of DOX as magnetic resonance imaging guided drug–PDT dual-therapy.

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Article information

DOI: https://doi.org/10.1039/C9CC01957J
Article type: Communication
Submitted: 11 Mar 2019
Accepted: 01 May 2019
First published: 02 May 2019

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Chem. Commun., 2019,55, 6241-6244

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GSH-activated MRI-guided enhanced photodynamic- and chemo-combination therapy with a MnO₂-coated porphyrin metal organic framework

X. Tian, P. Cao, H. Zhang, Y. Li and X. Yin, Chem. Commun., 2019, 55, 6241 DOI: 10.1039/C9CC01957J

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Chemical Communications