Issue 46, 2019

Unique Tyr-heme double cross-links in F43Y/T67R myoglobin: an artificial enzyme with a peroxidase activity comparable to that of native peroxidases

Abstract

The X-ray crystal structure of F43Y/T67R myoglobin revealed unique Tyr-heme double cross-links between Tyr43 and the heme 4-vinyl group, which represents a novel post-translational modification of heme proteins. Moreover, with the feature of a distal His–Arg pair, the designed artificial enzyme exhibited a peroxidase activity comparable to that of native peroxidases, such as the most efficient horseradish peroxidase.

Graphical abstract: Unique Tyr-heme double cross-links in F43Y/T67R myoglobin: an artificial enzyme with a peroxidase activity comparable to that of native peroxidases

Supplementary files

Article information

Article type
Communication
Submitted
08 Apr 2019
Accepted
15 May 2019
First published
15 May 2019

Chem. Commun., 2019,55, 6610-6613

Unique Tyr-heme double cross-links in F43Y/T67R myoglobin: an artificial enzyme with a peroxidase activity comparable to that of native peroxidases

C. Liu, H. Yuan, F. Liao, C. Wei, K. Du, S. Gao, X. Tan and Y. Lin, Chem. Commun., 2019, 55, 6610 DOI: 10.1039/C9CC02714A

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