A dual-mode nanoprobe for evaluation of the autophagy level affected by photothermal therapy

Jia Liu; Yining Qu; Tingting Zheng; Yang Tian

doi:10.1039/C9CC03319J

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A dual-mode nanoprobe for evaluation of the autophagy level affected by photothermal therapy†

Jia Liu,^a Yining Qu,^a Tingting Zheng

*^a and Yang Tian

*^a

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* Corresponding authors

^a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Dongchuan Road 500, Shanghai 200241, P. R. China
E-mail: ttzheng@chem.ecnu.edu.cn, ytian@chem.ecnu.edu.cn

Abstract

A novel dual-mode nanoprobe (Apt@MNPS) was created for the detection of autophagy-related miRNAs to monitor the autophagic level and study the effect of PTT on autophagy. Interestingly, using our developed probe, PTT was found to be able to activate the autophagy by down regulation of miR-18a* and miR-4802, which in turn restricted the PTT efficiency for cancer.

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Article information

DOI: https://doi.org/10.1039/C9CC03319J
Article type: Communication
Submitted: 30 Apr 2019
Accepted: 15 Jul 2019
First published: 16 Jul 2019

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Chem. Commun., 2019,55, 9673-9676

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A dual-mode nanoprobe for evaluation of the autophagy level affected by photothermal therapy

J. Liu, Y. Qu, T. Zheng and Y. Tian, Chem. Commun., 2019, 55, 9673 DOI: 10.1039/C9CC03319J

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Chemical Communications

A dual-mode nanoprobe for evaluation of the autophagy level affected by photothermal therapy†

Abstract

Supplementary files

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A dual-mode nanoprobe for evaluation of the autophagy level affected by photothermal therapy

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