Issue 62, 2019
From the journal:

Chemical Communications

Stabilization of microtubules by encapsulation of the GFP using a Tau-derived peptide†

Hiroshi Inaba, ORCID logo *ab   Takahisa Yamamoto,a   Takashi Iwasaki,c   Arif Md. Rashedul Kabir, ORCID logo d   Akira Kakugo, ORCID logo de   Kazuki Sadade  and  Kazunori Matsuura ORCID logo *ab  

* Corresponding authors

a Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Koyama-Minami 4-101, Tottori 680-8552, Japan
E-mail: hinaba@tottori-u.ac.jp, ma2ra-k@tottori-u.ac.jp

b Centre for Research on Green Sustainable Chemistry, Tottori University, Koyama-Minami 4-101, Tottori 680-8552, Japan

c Department of Bioresources Science, Graduate School of Agricultural Sciences, Tottori University, Koyama-Minami 4-101, Tottori 680-8553, Japan

d Faculty of Science, Hokkaido University, Kita 10 Nishi 8, Kita-ku, Sapporo 060-0810, Japan

e Graduate School of Chemical Sciences and Engineering, Hokkaido University, Kita 10 Nishi 8, Kita-ku, Sapporo 060-0810, Japan

Abstract

We constructed GFP-encapsulated microtubules (MTs) using a Tau-derived peptide which binds to their interior. The encapsulation of the GFP dramatically increased the rigidity of MTs, resulting in their enhanced velocity on a kinesin-coated substrate. Moreover, the GFP-encapsulated MTs were significantly more stable than normal MTs.

Graphical abstract: Stabilization of microtubules by encapsulation of the GFP using a Tau-derived peptide

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Article information

DOI
https://doi.org/10.1039/C9CC04345D
Article type
Communication
Submitted
06 Jun 2019
Accepted
26 Jun 2019
First published
26 Jun 2019

Chem. Commun., 2019,55, 9072-9075

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Stabilization of microtubules by encapsulation of the GFP using a Tau-derived peptide

H. Inaba, T. Yamamoto, T. Iwasaki, A. Md. R. Kabir, A. Kakugo, K. Sada and K. Matsuura, Chem. Commun., 2019, 55, 9072 DOI: 10.1039/C9CC04345D

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