Issue 73, 2019
From the journal:

Chemical Communications

A photo-stable and reversible pH-responsive nano-agent based on the NIR phenazine dye for photoacoustic imaging-guided photothermal therapy†

Yongchao Yan,‡a   Hao Fu,‡b   Jian Wang,a   Chuanrong Chen,b   Qi Wang, ORCID logo a   Yourong Duan ORCID logo *b  and  Jianli Hua ORCID logo *a  

* Corresponding authors

a Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China
E-mail: jlhua@ecust.edu.cn

b State Key Laboratory of Oncogenes and Related Genes, Reiji Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, 25 Xietu Road, Shanghai 200032, P. R. China
E-mail: yrduan@shsci.org

Abstract

Different from traditional “always on” photothermal therapy (PTT) agents, tumor microenvironment responsive agents showed more tumor specificity and lower photo-toxicity to normal tissues. Herein, a photo-stable and reversible pH responsive phenazine dye (PIOH) was synthesized and assembled with liposomes forming nanoparticles (PIOH-NPs), which exhibited a strong NIR absorption in a weak acid environment and were successfully utilized for photoacoustic (PA) imaging-guided photothermal therapy in mice.

Graphical abstract: A photo-stable and reversible pH-responsive nano-agent based on the NIR phenazine dye for photoacoustic imaging-guided photothermal therapy

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Article information

DOI
https://doi.org/10.1039/C9CC05624F
Article type
Communication
Submitted
20 Jul 2019
Accepted
14 Aug 2019
First published
14 Aug 2019

Chem. Commun., 2019,55, 10940-10943

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A photo-stable and reversible pH-responsive nano-agent based on the NIR phenazine dye for photoacoustic imaging-guided photothermal therapy

Y. Yan, H. Fu, J. Wang, C. Chen, Q. Wang, Y. Duan and J. Hua, Chem. Commun., 2019, 55, 10940 DOI: 10.1039/C9CC05624F

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