Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

Ao Jiang; Guang Chen; Jie Xu; Yuxia Liu; Guanghui Zhao; Zhenjun Liu; Tao Chen; Yulin Li; Tony D. James

doi:10.1039/C9CC05759E

Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication†

Ao Jiang,^a Guang Chen,

*^a Jie Xu,^a Yuxia Liu,

^a Guanghui Zhao,^a Zhenjun Liu,^a Tao Chen,^ab Yulin Li^ab and Tony D. James

*^ac

Author affiliations

* Corresponding authors

^a The Key Laboratory of Life-Organic Analysis, Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University, The school attached to Qufu Normal University, Qufu 273165, China
E-mail: chenandguang@163.com

^b Key Laboratory of Tibetan Medicine Research & Qinghai Key Laboratory of Qinghai-Tibet Plateau Biological Resources, Northwest Institute of Plateau Biology, Chinese Academy of Science, Xining 810001, Qinghai, P. R. China

^c Department of Chemistry, University of Bath, Bath, UK
E-mail: t.d.james@bath.ac.uk

Abstract

We report on a dual ratiometric two-photon fluorescent probe for in situ sensing of mitochondrial CE activity and pH. Using the probe it is possible to visualize the CE-mediated acidification of hepatoma cells and hepatic tissues during medication with antipyretic anti-inflammatory drugs.

This article is part of the themed collection: The Mechanics of Supramolecular Chemistry

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DOI: https://doi.org/10.1039/C9CC05759E
Article type: Communication
Submitted: 25 Jul 2019
Accepted: 19 Aug 2019
First published: 03 Sep 2019
This article is Open Access

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Chem. Commun., 2019,55, 11358-11361

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Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

A. Jiang, G. Chen, J. Xu, Y. Liu, G. Zhao, Z. Liu, T. Chen, Y. Li and T. D. James, Chem. Commun., 2019, 55, 11358 DOI: 10.1039/C9CC05759E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Chemical Communications

Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication†

Abstract

Supplementary files

Article information

Download Citation

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Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

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