A biotinylated ruthenium(II) photosensitizer for tumor-targeted two-photon photodynamic therapy

Jia Li; Leli Zeng; Kai Xiong; Thomas W. Rees; Chengzhi Jin; Weijun Wu; Yu Chen; Liangnian Ji; Hui Chao

doi:10.1039/C9CC05826E

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A biotinylated ruthenium(ii) photosensitizer for tumor-targeted two-photon photodynamic therapy†

Jia Li,^a Leli Zeng,^a Kai Xiong,^a Thomas W. Rees,^a Chengzhi Jin,^a Weijun Wu,

^a Yu Chen,

*^a Liangnian Ji^a and Hui Chao

*^ab

Author affiliations

* Corresponding authors

^a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China
E-mail: ceschh@mail.sysu.edu.cn, chenyu63@mail.sysu.edu.cn

^b MOE Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China

Abstract

Platinum-resistant cancer cells are sensitive to changes in the levels of reactive oxidative species (ROS). Herein, we design a biotin-modified Ru(II) complex as a photosensitizer (denoted as Ru-Biotin). Ru-Biotin can selectively target cancer cells and produce vast amounts of singlet oxygen under two-photon excitation at 820 nm leading to cell apoptosis. Ru-Biotin is therefore an excellent candidate to overcome platinum resistance via two-photon photodynamic therapy.

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Article information

DOI: https://doi.org/10.1039/C9CC05826E
Article type: Communication
Submitted: 26 Jul 2019
Accepted: 19 Aug 2019
First published: 19 Aug 2019

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Chem. Commun., 2019,55, 10972-10975

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A biotinylated ruthenium(II) photosensitizer for tumor-targeted two-photon photodynamic therapy

J. Li, L. Zeng, K. Xiong, T. W. Rees, C. Jin, W. Wu, Y. Chen, L. Ji and H. Chao, Chem. Commun., 2019, 55, 10972 DOI: 10.1039/C9CC05826E

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Chemical Communications

A biotinylated ruthenium(ii) photosensitizer for tumor-targeted two-photon photodynamic therapy†

Abstract

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A biotinylated ruthenium(II) photosensitizer for tumor-targeted two-photon photodynamic therapy

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