Issue 78, 2019
From the journal:

Chemical Communications

In situ condensation of an anti-cancer drug into fibrin gel enabling effective inhibition of tumor cell growth†

Masayasu Kuwahara, ORCID logo *a   Hiroto Fujita,a   Yuka Kataoka,a   Yasuyo Nakajima, ORCID logo b   Masanobu Yamadab  and  Naoki Sugimoto ORCID logo cd  

* Corresponding authors

a Graduate School of Integrated Basic Sciences, Nihon University, 3-25-40 Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan
E-mail: mkuwa@chs.nihon-u.ac.jp

b Department of Internal Medicine, Division of Endocrinology and Metabolism, Graduate School of Medicine, Gunma University, 3-39-15 Showa-machi, Maebashi, Japan

c Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Kobe, Japan

d Graduate School of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamimachi, Kobe, Japan

Abstract

We show herein the highly effective inhibition of tumor cell growth using a gel consisting of a fibrin polymer formed with the in situ condensation of a camptothecin (CPT) derivative as an anti-cancer drug, which is efficiently conveyed with a carrier aptamer from a solution to the gel in a phenomenon, called selective oligonucleotide entrapment in fibrin polymers (SOEF).

Graphical abstract: In situ condensation of an anti-cancer drug into fibrin gel enabling effective inhibition of tumor cell growth

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Article information

DOI
https://doi.org/10.1039/C9CC06418D
Article type
Communication
Submitted
19 Aug 2019
Accepted
02 Sep 2019
First published
03 Sep 2019

Chem. Commun., 2019,55, 11679-11682

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In situ condensation of an anti-cancer drug into fibrin gel enabling effective inhibition of tumor cell growth

M. Kuwahara, H. Fujita, Y. Kataoka, Y. Nakajima, M. Yamada and N. Sugimoto, Chem. Commun., 2019, 55, 11679 DOI: 10.1039/C9CC06418D

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