Silver-mediated oxidative 1,2-alkylesterification of styrenes with nitriles and acids via C(sp3)–H functionalization

Abstract

A new silver-mediated 1,2-alkylesterification of alkenes with nitriles and acids promoted by a catalytic amount of nickel catalyst for producing acyloxylated nitriles has been developed via a C(sp³)–H functionalization process. By employing the NiI₂ and Ag₂CO₃ catalytic systems, the method features broad substrate scope with respect to carboxylic acids, including linear alkyl acids, cyclic acids, aryl acids and amino acids.