Issue 89, 2019
From the journal:

Chemical Communications

Degradation of phthalic acid esters (PAEs) by an enzyme mimic and its application in the degradation of intracellular DEHP†

Xia Li,‡a   Jianpeng Li,‡b   Junxiang Zhu, ORCID logo c   Sijia Hao,a   Guozhen Fang, ORCID logo a   Jifeng Liu ORCID logo *a  and  Shuo Wang*ad  

* Corresponding authors

a State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, P. R. China
E-mail: liujifeng111@gmail.com, s.wang@tust.edu.cn

b School of Food Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Ji’nan, Shandong 250353, P. R. China

c College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong 266109, P. R. China

d Research Center of Food Science and Human Health, School of Medicine, Nankai University, Tianjin 300071, P. R. China

Abstract

Here, an enzyme mimic inspired by serine proteases was developed for the degradation of PAEs. This enzyme mimic, comprised an active site (SHD), a self-assembling polypeptide (LKLKLKL), a spacer (GGG) and a polymerizable site (DOPA) and showed high activity towards the degradation of DEHP in cells.

Graphical abstract: Degradation of phthalic acid esters (PAEs) by an enzyme mimic and its application in the degradation of intracellular DEHP

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Article information

DOI
https://doi.org/10.1039/C9CC06794A
Article type
Communication
Submitted
02 Sep 2019
Accepted
09 Oct 2019
First published
10 Oct 2019

Chem. Commun., 2019,55, 13458-13461

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Degradation of phthalic acid esters (PAEs) by an enzyme mimic and its application in the degradation of intracellular DEHP

X. Li, J. Li, J. Zhu, S. Hao, G. Fang, J. Liu and S. Wang, Chem. Commun., 2019, 55, 13458 DOI: 10.1039/C9CC06794A

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