A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery

Xiaodong Zeng; Liru Xie; Deliang Chen; Shanshan Li; Jinxia Nong; Bo Wang; Lin Tang; Qianqian Li; Yang Li; Zixin Deng; Xuechuan Hong; Mingfu Wu; Yuling Xiao

doi:10.1039/C9CC07694H

A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery†

Xiaodong Zeng,

‡^abc Liru Xie,‡^a Deliang Chen,

^d Shanshan Li,^b Jinxia Nong,^b Bo Wang,^a Lin Tang,^b Qianqian Li,^b Yang Li,^b Zixin Deng,^bc Xuechuan Hong,

^bce Mingfu Wu*^ac and Yuling Xiao

*^bc

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* Corresponding authors

^a State Key Laboratory of Virology, Department Gynecology, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
E-mail: mingfuwutj@163.com

^b Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan, Hubei 430071, China
E-mail: xiaoyl@whu.edu.cn

^c Innovation Center for Traditional Tibetan Medicine Modernization and Quality Control, Medical College, Tibet University, Lhasa, Xizang 850000, China

^d Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou, Jiangxi 341000, China

^e Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, China

Abstract

A novel bright near-infrared II (NIR-II, 1000–1700 nm) fluorescent probe with excellent water-solubility, superior photostability, and excellent in vitro and in vivo biocompatibility was facilely synthesized for in vivo biomedical imaging of xenograft breast tumor and chemically induced spontaneous breast carcinoma. To the best of our knowledge, it is the first time that the superior practical applications of this NIR-II probe in dimethylbenzanthracene (DMBA)-induced rat mammary carcinoma imaging and image-guided rat carcinoma surgery were demonstrated.

Chemical Communications

A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery†

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A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery

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