A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8†
Francesca
Nardelli, 
‡a
Michela
Ghitti,
*a
Giacomo
Quilici,
a
Alessandro
Gori,
b
Qingqiong
Luo,
c
Andrea
Berardi,
a
Angelina
Sacchi,
a
Matteo
Monieri,
a
Greta
Bergamaschi,
b
Fuxiang
Chen,
c
Angelo
Corti,
*ae
Flavio
Curnis
*a
and
Giovanna
Musco
*a
‡a
Michela
Ghitti,
*a
Giacomo
Quilici,
a
Alessandro
Gori,
b
Qingqiong
Luo,
c
Andrea
Berardi,
a
Angelina
Sacchi,
a
Matteo
Monieri,
a
Greta
Bergamaschi,
b
Fuxiang
Chen,
c
Angelo
Corti,
*ae
Flavio
Curnis
*a
and
Giovanna
Musco
*a
Abstract
Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications.
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