Synthesis, characterization and biological investigation of platinum(ii) complexes with asparagusic acid derivatives as ligands

Abstract

After more than 50 years of platinum-based anticancer research only three compounds are in clinical use worldwide. The use of the well-known lead compound of this class of anticancer agents, cisplatin, is limited by its side effects and varying resistance mechanisms. Therefore, we report on platinum(II) compounds with asparagusic acid derivatives as ligands which show interesting anticancer results on cisplatin resistant cell lines.