Cleaving DNA-model phosphodiester with Lewis acid–base catalytic sites in bifunctional Zr–MOFs

Abstract

Organophosphates exist in many biomolecules. The design of artificial nucleases for efficient P–O bond cleavage is essential for the fields of genetic engineering and molecular biology. Herein, metal–organic frameworks (MOFs) with cooperatively isolated multi-catalytic active sites were utilized as heterogeneous catalysts for the hydrolytic cleavage of bis(p-nitrophenyl) phosphate (BNPP).