ESIPT-based fluorescence probe for the ratiometric detection of superoxide

Luling Wu; Liyuan Liu; Hai-Hao Han; Xue Tian; Maria L. Odyniec; Lei Feng; Adam C. Sedgwick; Xiao-Peng He; Steven D. Bull; Tony D. James

doi:10.1039/C8NJ05656K

ESIPT-based fluorescence probe for the ratiometric detection of superoxide†

Luling Wu,

^a Liyuan Liu,

^a Hai-Hao Han,

^b Xue Tian,

^a Maria L. Odyniec,

^a Lei Feng,

^ac Adam C. Sedgwick,

*^d Xiao-Peng He,

^b Steven D. Bull

*^a and Tony D. James

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Bath, Bath, UK
E-mail: t.d.james@bath.ac.uk, s.d.bull@bath.ac.uk

^b Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, China

^c College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, College of Pharmacy, Dalian Medical University, Dalian 116044, China

^d Department of Chemistry, University of Texas at Austin, 105 E 24th street A5300, Austin, TX 78712-1224, USA
E-mail: a.c.sedgwick@utexas.edu

Abstract

A simple ESIPT-based fluorescence probe (HMBT-LW) was developed for the detection of superoxide (O₂˙⁻). HMBT-LW was synthesised over two steps and was shown to rapidly detect low concentrations of O₂˙⁻ (limit of detection = 7.4 μM), fully reacting within two minutes. Furthermore, HMBT-LW demonstrated excellent selectivity and sensitivity towards O₂˙⁻.

This article is part of the themed collection: The Mechanics of Supramolecular Chemistry

New Journal of Chemistry

ESIPT-based fluorescence probe for the ratiometric detection of superoxide†

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ESIPT-based fluorescence probe for the ratiometric detection of superoxide

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