Transition metal-free synthesis of fluoroalkylated oxindoles via base-mediated fluoroalkylation of N-arylacrylamides with RFI

Abstract

A base-mediated tandem radical procedure for the synthesis of fluoroalkylated oxindoles via the cyclization reaction of N-arylacrylamides with R_FI was developed. With this facile and practical synthetic method, a wide range of 3-(2-perfluoroalkyl)indolin-2-ones could be obtained in good yields with high stereoselectivity.