Kazuya Douki, Jun Shimokawa and Masato Kitamura
Org. Biomol. Chem., 2019,17, 1727-1730
DOI:
10.1039/C8OB02320D,
Communication
The core skeleton of phalarine was rapidly synthesised through novel palladium-catalysed dearomative spirocyclisation and a palladium-catalysed Wacker-carbonylative cyclisation cascade. The two key steps allowed for the efficient construction of a tricyclic propeller skeleton bearing contiguous tetrasubstituted carbon centres, within 3 steps from a topologically planar precursor.
