Gold(i) catalysed regio- and stereoselective intermolecular hydroamination of internal alkynes: towards functionalised azoles†
Christophe
Michon, 
*ab
Fady
Nahra,
d
Catherine S. J.
Cazin,
d
Francine
Agbossou-Niedercorn
ab
and
Steven P.
Nolan
*de
*ab
Fady
Nahra,
d
Catherine S. J.
Cazin,
d
Francine
Agbossou-Niedercorn
ab
and
Steven P.
Nolan
*de
Abstract
Gold(I) catalysed regio- and stereoselective intermolecular hydroamination of internal alkynes was developed for the effective synthesis of a series of (Z)-functionalised vinylazoles under solvent free conditions. The catalytic hydrogenation of the resulting enamines leads to substituted saturated azoles in good yields.
- This article is part of the themed collections: Synthetic methodology in OBC and Catalysis & biocatalysis in OBC
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