Takashi Koike and Munetaka Akita
Org. Biomol. Chem., 2019,17, 5413-5419
DOI:
10.1039/C9OB00734B,
Review Article
Recently, photoinduced radical difluoromethylation has emerged as a step-economical synthetic method of CHF2-containing compounds. In this article, difluoromethylation of alkenes, isonitriles and aryl bromides promoted by photoredox catalysis is described together with a non-catalytic photoinduced system. Representative reactions will be discussed for each highlighted difluoromethylating reagent. In addition, related monofluoromethylation with their corresponding monofluoromethylating reagents is also discussed.