Iridium-catalyzed intramolecular enantioselective allylation of quinazolin-4(3H)-one derivatives

Abstract

An efficient iridium-catalyzed intramolecular enantioselective allylation of quinazolin-4(3H)-one derivatives has been developed, and the corresponding products were obtained with high reactivity and high to excellent enantioselectivity with tolerance of some functional groups, in which our developed chiral cyclic phosphoramidite ligands greatly promoted the iridium-catalyzed reactivity and enantioselectivity.