Three-component difluoroalkylamination of alkenes mediated by photoredox and iron cooperative catalysis

Abstract

A three-component difluoroalkylamination of alkenes with BrCF₂CO₂Et and amines mediated by visible-light photoredox and iron cooperative catalysis is described. Electron rich, electron poor, and internal styrenes are all tolerated giving the desired products in good yields. The Csp³–Csp³ and Csp³–N bonds are simultaneously formed under mild conditions. A radical pathway is proposed by experimental studies.