Issue 11, 2019
From the journal:

Inorganic Chemistry Frontiers

A quinoline-based probe for effective and selective sensing of aspartic acid in aqueous medium: in vitro and in vivo live cell imaging†

C. Elamathi,a   R. J. Butcher,b   A. Mohankumar, ORCID logo c   P. Sundararaj,c   A. Madankumar, ORCID logo d   P. Kalaivanie  and  R. Prabhakaran ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Bharathiar University, Coimbatore – 641 046, India
E-mail: rpnchemist@gmail.com
Fax: +91-422-2422387
Tel: +91-422-2428319

b Department of Inorganic and Structural Chemistry, Howard University, Washington, DC 20059, USA

c Department of Zoology, Bharathiar University, Coimbatore 641 046, India

d Cancer Biology Lab, Molecular and Nanomedicine Research Unit, Sathyabama Institute of Science and Technology, Chennai 600 119, India

e Department of Chemistry, Nirmala College for Women, Bharathiar University, Coimbatore – 641046, India

Abstract

A naturally occurring nitrogen heterocycle-based Schiff base sensor 8-methyl-2-oxo-1,2-dihydroquinoline-3-carboxaldehyde-4N-phenylsemicarbazone (8MPS) was synthesized; a highly sensitive and selective “on–off–on” chemosensor for aspartic acid in aqueous solution was established. In vitro live cell imaging of 8MPS, 8MPSC and 8MPSCA against human breast cancer cells and in vivo imaging using C. elegans as a model have been successfully demonstrated. The sensing probe (8MPS) showed enhanced green fluorescence.

Graphical abstract: A quinoline-based probe for effective and selective sensing of aspartic acid in aqueous medium: in vitro and in vivo live cell imaging

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Article information

DOI
https://doi.org/10.1039/C9QI00992B
Article type
Research Article
Submitted
06 Aug 2019
Accepted
16 Sep 2019
First published
18 Sep 2019

Inorg. Chem. Front., 2019,6, 3237-3244

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A quinoline-based probe for effective and selective sensing of aspartic acid in aqueous medium: in vitro and in vivo live cell imaging

C. Elamathi, R. J. Butcher, A. Mohankumar, P. Sundararaj, A. Madankumar, P. Kalaivani and R. Prabhakaran, Inorg. Chem. Front., 2019, 6, 3237 DOI: 10.1039/C9QI00992B

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