Carbene-catalyzed oxidative acylation promoted by an unprecedented oxidant CCl3CN

Abstract

An unprecedented example of a NHC-catalyzed acylation reaction promoted by an oxidant CCl₃CN is described. This protocol features several advantages, including mild reaction conditions, broad substrate scope, and easy operation. In addition, low cost, low boiling point, and small molecular weight allow CCl₃CN to be an attractive and amenable oxidant. Meanwhile, this formal dehydrogenative coupling reaction of aldehydes and alcohols involves a hydride transfer process.