Scandium-catalyzed electrophilic alkene difunctionalization: regioselective synthesis of thiosulfone derivatives

Abstract

A scandium(III)-catalyzed electrophilic alkene difunctionalization reaction with the synergistic formation of two C–S bonds has been developed. This reaction features a broad substrate scope, simple procedures, 100% atom economy, and a reversed regioselectivity compared to previously studied alkene sulfonylation methods.