Issue 15, 2019

A one-pot protocol for the synthesis of β-ketosulfones from α,α-dibromoketones

Abstract

A one-pot debromination/sulfonylation strategy was developed for the direct transformation of α,α-dibromoketones into β-ketosulfones in the presence of sulfinate salts in a methanol solution. A broad range of α,α-dibromoketones react smoothly with various aryl/alkyl sulfinates under neutral and catalyst-free conditions, affording diverse β-ketosulfones in good to excellent yields. The plausible mechanism was studied.

Graphical abstract: A one-pot protocol for the synthesis of β-ketosulfones from α,α-dibromoketones

Supplementary files

Article information

Article type
Research Article
Submitted
27 Mar 2019
Accepted
30 May 2019
First published
12 Jun 2019

Org. Chem. Front., 2019,6, 2647-2653

A one-pot protocol for the synthesis of β-ketosulfones from α,α-dibromoketones

B. Lin, J. Kuang, J. Chen, Z. Hua, V. Khakyzadeh and Y. Xia, Org. Chem. Front., 2019, 6, 2647 DOI: 10.1039/C9QO00440H

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