Issue 43, 2019, Issue in Progress
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RSC Advances

Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging†

Vivek Thakare,ab   Vu-Long Tran,cd   Marco Natuzzi,c   Eloïse Thomas,c   Mathieu Moreau,a   Anthony Romieu, ORCID logo ae   Bertrand Collin,af   Alan Courteau,f   Jean-Marc Vrigneaud,f   Cédric Louis,d   Stéphane Roux,g   Frédéric Boschetti,b   Olivier Tillement,ch   François Lux ORCID logo ch  and  Franck Denat ORCID logo *a  

* Corresponding authors

a Institut de Chimie Moléculaire de l’Université de Bourg, UMR 6302, CNRS, Université Bourgogne Franche-Comté, 9 Avenue Alain Savary, Dijon, France
E-mail: franck.denat@u-bourgogne.fr

b CheMatech, 2 rue Pauline Kergomard, Dijon, France

c Univ Lyon, Université Claude Bernard Lyon 1, CNRS, Institut Lumière Matière, Lyon, France

d Nano H SAS, 2 Place de l’Europe, 38070 Saint Quentin Fallavier, France

e Institut Universitaire de France, 1, Rue Descartes, Bâtiment MONGE, 75231 Paris, France

f Georges-François LECLERC Cancer Center – UNICANCER, 1 rue Pr Marion, Dijon, France

g Institut UTINAM, UMR6213, CNRS, Université de Bourgogne Franche-Comté, 16 route de Gray, Besançon, France

h NH TherAguix SAS, F69100 Villeurbanne, France

Abstract

A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with 64Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging.

Graphical abstract: Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging

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Article information

DOI
https://doi.org/10.1039/C9RA00365G
Article type
Paper
Submitted
15 Jan 2019
Accepted
01 Aug 2019
First published
09 Aug 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 24811-24815

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Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging

V. Thakare, V. Tran, M. Natuzzi, E. Thomas, M. Moreau, A. Romieu, B. Collin, A. Courteau, J. Vrigneaud, C. Louis, S. Roux, F. Boschetti, O. Tillement, F. Lux and F. Denat, RSC Adv., 2019, 9, 24811 DOI: 10.1039/C9RA00365G

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