Issue 51, 2019, Issue in Progress

Development of a fused imidazo[1,2-a]pyridine based fluorescent probe for Fe3+ and Hg2+ in aqueous media and HeLa cells

Abstract

A new fluorescent sensor 5 based on a fused imidazopyridine scaffold has been designed and synthesized via cascade cyclization. The reaction features the formation of three different C–N bonds in sequence. Imidazopyridine based fluorescent probe 5 exhibits highly sensitive and selective fluorescent sensing for Fe3+(‘turn-on’) and Hg2+(‘turn-off’). The excellent selectivity of imidazopyridine for Fe3+/Hg2+ was not hampered in the presence of any of the competing cations. The limit of detection (LOD) of 5 toward Fe3+ and Hg2+ has been estimated to be 4.0 ppb and 1.0 ppb, respectively, with a good linear relationship (R2 = 0.99). Notably, 5 selectively detects Fe3+/Hg2+ through fluorescence enhancement signalling both in vitro and in HeLa cells.

Graphical abstract: Development of a fused imidazo[1,2-a]pyridine based fluorescent probe for Fe3+ and Hg2+ in aqueous media and HeLa cells

Supplementary files

Article information

Article type
Paper
Submitted
24 Jun 2019
Accepted
15 Sep 2019
First published
20 Sep 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 29856-29863

Development of a fused imidazo[1,2-a]pyridine based fluorescent probe for Fe3+ and Hg2+ in aqueous media and HeLa cells

S. Srivastava, N. Thakur, A. Singh, P. Shukla, V. K. Maikhuri, N. Garg, A. Prasad and R. Pandey, RSC Adv., 2019, 9, 29856 DOI: 10.1039/C9RA04743C

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