SO2F2 mediated cascade dehydrogenative Morita–Baylis–Hillman reaction of the C(sp3)–H of primary alcohols with the C(sp2)–H of electron-deficient olefins for the assembly of allylic alcohols

Abstract

A cascade dehydrogenative Morita–Baylis–Hillman reaction of the C(sp³)–H of primary alcohols with the C(sp²)–H of electron-deficient olefins for forming allylic alcohols mediated by SO₂F₂ was developed. This method provides a mild process for the preparation of allylic alcohol moieties without the requirement of transition metals.