Issue 15, 2019

MoS2 quantum dots as a unique fluorescent “turn-off–on” probe for the simple and rapid determination of adenosine triphosphate

Abstract

We report a one-step hydrothermal method for the preparation of fluorescent molybdenum disulfide quantum dots (MoS2 QDs) and demonstrate the feasibility of fluorescent “turn-off–on” sensing of adenosine triphosphate (ATP) by using the MoS2 QDs. MoS2 QDs having strong blue-green fluorescence at 506 nm and good water-solubility were successfully synthesized by using ammonium tetrathiomolybdate as a single precursor. The fluorescence of MoS2 QDs was first quenched by Fe3+ through the formation of a MoS2 QDs/Fe3+ complex. ATP with the ability to coordinate with Fe3+ caused the dissociation of MoS2 QDs/Fe3+, resulting in the final release of MoS2 QDs and the recovery of fluorescence through a one-step competitive chelating process that took only 10 min to reach equilibrium at room temperature (RT). Facile and rapid sensing of Fe3+ and ATP could thus be achieved through the fluorescent “turn-off–on” strategy. Good linear relationships were obtained over the concentration ranges of 0–200 μM for Fe3+ and 0–140 μM for ATP with a lowest detectable concentration of 5 μM for ATP. Satisfactory results were obtained when the method was applied to a standard addition recovery trial of ATP in human serum samples. No complex surface modification during the preparation or detection process was needed based on the fluorescent “turn-off–on” method of the MoS2 QDs, which suggests its great potential in fluorescent sensing.

Graphical abstract: MoS2 quantum dots as a unique fluorescent “turn-off–on” probe for the simple and rapid determination of adenosine triphosphate

Supplementary files

Article information

Article type
Paper
Submitted
28 Jan 2019
Accepted
08 Mar 2019
First published
09 Mar 2019

J. Mater. Chem. B, 2019,7, 2549-2556

MoS2 quantum dots as a unique fluorescent “turn-off–on” probe for the simple and rapid determination of adenosine triphosphate

Y. Zhong and T. Yi, J. Mater. Chem. B, 2019, 7, 2549 DOI: 10.1039/C9TB00191C

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