A modular theranostic platform for tumor therapy and its metabolic studies

Abstract

Theranostic systems are able to detect and treat diseases with only one procedure, thus greatly lessening the pain of patients. Since each patient's disease can be considered as a new clinical subtype, it is essential to develop theranostic nanomaterials with changeable functions for personal treatment. In this work, a novel modular theranostic platform was designed to control the stimuli-responsive drug release. As a patch board, mesoporous silica nanoparticles (MSNs) were functionalized with a linear pH-responsive benzimidazole (Bz)-polyethylene glycol (PEG) chain containing a redox-responsive ferrocene (Fc) oxide stopper at the end. As the plug, the β-CD ring was initially located at the Bz position. In an acidic tumor microenvironment, the pH sensitive Bz was protonated and the complex formation constant between Bz and β-CD decreased. At the same time, the complex formation constant between Fc and β-CD increased remarkably. As a result, the β-CD ring would depart from the nanoparticle surface to the Fc position at pH 6.2 & 10 mM GSH, physically causing an “And” logic gate type drug release. Herein, a “plug and play” method was used to achieve changeable functions with only one platform. By plugging modified β-CD into the patch board, theranostic systems with changeable functions can be achieved easily.