Issue 30, 2019

Engineering FeCo alloy@N-doped carbon layers by directly pyrolyzing Prussian blue analogue: new peroxidase mimetic for chemiluminescence glucose biosensing

Abstract

Herein, we report the synthesis of FeCo alloy@N-doped carbon layers (FeCo@NC), a new peroxidase mimetic, by directly pyrolyzing the FeIII–Co Prussian blue analogue (FeIII–Co PBA). The FeCo@NC composite showed excellent peroxidase-like activity due to its highly active FeCo alloy, M–N species (Co–N and Fe–N) and N-doped carbon layers with hierarchical pore nanostructures, which were formed via simple heat treatment of FeIII–Co PBA without additional C and N sources. In particular, the obtained FeCo@NC hybrid presented high CL activity with more than 85-fold enhancement in the CL emission of the H2O2–luminol system, and long-term stability compared with FeCo alloy nanoparticles. The CL response showed a linear range of 0.01–40 μM H2O2 with a limit of detection of 2.5 nM. When coupled with glucose oxidase, we developed a new CL sensing method for the detection of glucose in the linear range of 10 nM to 10 μM with a detection limit of 8.5 nM. This FeCo@NC-based glucose biosensor displayed rapidity, high precision and good reproducibility when utilized to analyze real biological samples. Expectedly, FeCo@NC, as a new peroxidase mimetic, exhibits great potential for monitoring glucose levels in clinical diagnosis.

Graphical abstract: Engineering FeCo alloy@N-doped carbon layers by directly pyrolyzing Prussian blue analogue: new peroxidase mimetic for chemiluminescence glucose biosensing

Supplementary files

Article information

Article type
Paper
Submitted
24 Apr 2019
Accepted
23 Jun 2019
First published
25 Jun 2019

J. Mater. Chem. B, 2019,7, 4661-4668

Engineering FeCo alloy@N-doped carbon layers by directly pyrolyzing Prussian blue analogue: new peroxidase mimetic for chemiluminescence glucose biosensing

Y. Lu, X. Zhang, X. Mao and Y. Huang, J. Mater. Chem. B, 2019, 7, 4661 DOI: 10.1039/C9TB00797K

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