Issue 7, 2020

Intact NMR spectroscopy: slow high-resolution magic angle spinning chemical shift imaging

Abstract

High-Resolution Magic-Angle Spinning Chemical Shift Imaging (HR-MAS CSI) has recently been explored for nuclear magnetic resonance (NMR) metabolomics and shows considerable promise in organism research. This is due to its ability to offer a supplemental dimension – spatial metabolic distribution – for profiling. However, HR-MAS CSI suffers from the large centrifugal stress exerted on the sample, which inevitably hinders the metabolic assessment. Herein, a slow sample spinning strategy was implemented and evaluated. The results demonstrate its potential as a highly informative profiling approach for intact specimens, with high quality data and feasibility.

Graphical abstract: Intact NMR spectroscopy: slow high-resolution magic angle spinning chemical shift imaging

Supplementary files

Article information

Article type
Communication
Submitted
16 Jan 2020
Accepted
26 Feb 2020
First published
04 Mar 2020

Analyst, 2020,145, 2520-2524

Intact NMR spectroscopy: slow high-resolution magic angle spinning chemical shift imaging

C. Lucas-Torres and A. Wong, Analyst, 2020, 145, 2520 DOI: 10.1039/D0AN00118J

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