Optimized fluorodendrimer-incorporated hybrid lipid–polymer nanoparticles for efficient siRNA delivery

Qingqing Xiong; Yujing Li; Kun Zhou; Ping Chen; Hua Guo; Lu Chen; Jianxun Ding; Tianqiang Song; Jinjun Shi

doi:10.1039/C9BM01738K

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Optimized fluorodendrimer-incorporated hybrid lipid–polymer nanoparticles for efficient siRNA delivery†

Qingqing Xiong,

^ab Yujing Li,^b Kun Zhou,^c Ping Chen,^a Hua Guo,^d Lu Chen,^a Jianxun Ding,

*^be Tianqiang Song*^a and Jinjun Shi^b

Author affiliations

* Corresponding authors

^a Department of Hepatobiliary Cancer, Liver Cancer Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, P. R. China
E-mail: tjchi@hotmail.com

^b Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA

^c Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

^d Department of Tumor Cell Biology, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, P. R. China

^e Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
E-mail: jxding@ciac.ac.cn

Abstract

Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid–polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.

Download options Please wait...

Supplementary files

Supplementary information PDF (602K)

Article information

DOI: https://doi.org/10.1039/C9BM01738K
Article type: Communication
Submitted: 29 Oct 2019
Accepted: 02 Jan 2020
First published: 06 Jan 2020

Download Citation

Biomater. Sci., 2020,8, 758-762

Permissions

Request permissions

Optimized fluorodendrimer-incorporated hybrid lipid–polymer nanoparticles for efficient siRNA delivery

Q. Xiong, Y. Li, K. Zhou, P. Chen, H. Guo, L. Chen, J. Ding, T. Song and J. Shi, Biomater. Sci., 2020, 8, 758 DOI: 10.1039/C9BM01738K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Biomaterials Science

Optimized fluorodendrimer-incorporated hybrid lipid–polymer nanoparticles for efficient siRNA delivery†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Optimized fluorodendrimer-incorporated hybrid lipid–polymer nanoparticles for efficient siRNA delivery

Social activity

Search articles by author

Spotlight

Advertisements