We report the first preparation of a monoclonal antibody (mAb) that can immobilize a palladium (Pd)-complex. The allylic amination reaction using a supramolecular catalyst consisting of the Pd-complex and mAb selectively gives the (R)-enantiomer product with an enantiomeric excess (ee) of 98 ± 2%. This is in sharp contrast to the reaction catalyzed by a conventional Pd-catalyst (ee < 2%).
Y. Kobayashi, K. Murata, A. Harada and H. Yamaguchi, Chem. Commun., 2020, 56, 1605 DOI: 10.1039/C9CC08756G
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