NAMI-A preferentially reacts with the Sp1 protein: understanding the anti-metastasis effect of the drug

Siming Yuan; Siming Chen; Han Wu; Huan Jiang; Shihui Zheng; Qianling Zhang; Yangzhong Liu

doi:10.1039/C9CC08775C

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NAMI-A preferentially reacts with the Sp1 protein: understanding the anti-metastasis effect of the drug†

Siming Yuan,^ab Siming Chen,^b Han Wu,^b Huan Jiang,^b Shihui Zheng,^b Qianling Zhang

*^a and Yangzhong Liu

*^b

Author affiliations

* Corresponding authors

^a Shenzhen Key Laboratory for Functional Polymer, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong, China
E-mail: zhql@szu.edu.cn

^b CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China
E-mail: liuyz@ustc.edu.cn

Abstract

NAMI-A is highly reactive to Sp1, a tumor metastasis related protein, resulting in the perturbation of the protein structure and disruption of the DNA recognition of Sp1. Interestingly, Sp1 is more susceptible than other zinc finger proteins to NAMI-A, suggesting that Sp1 could be the anti-metastasis target of NAMI-A.

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Article information

DOI: https://doi.org/10.1039/C9CC08775C
Article type: Communication
Submitted: 10 Nov 2019
Accepted: 24 Dec 2019
First published: 24 Dec 2019

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Chem. Commun., 2020,56, 1397-1400

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NAMI-A preferentially reacts with the Sp1 protein: understanding the anti-metastasis effect of the drug

S. Yuan, S. Chen, H. Wu, H. Jiang, S. Zheng, Q. Zhang and Y. Liu, Chem. Commun., 2020, 56, 1397 DOI: 10.1039/C9CC08775C

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Chemical Communications

NAMI-A preferentially reacts with the Sp1 protein: understanding the anti-metastasis effect of the drug†

Abstract

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NAMI-A preferentially reacts with the Sp1 protein: understanding the anti-metastasis effect of the drug

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