Construction of an iridium(III)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging

Yongxin Zhang; Hao Fu; Shuai Chen; Bingqing Liu; Wenfang Sun; Hui Gao

doi:10.1039/C9CC09357E

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Construction of an iridium(iii)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging†

Yongxin Zhang,‡^a Hao Fu,‡^a Shuai Chen,^a Bingqing Liu,

^b Wenfang Sun

^b and Hui Gao

*^a

Author affiliations

* Corresponding authors

^a Tianjin Key Laboratory of Drug Targeting and Bioimaging, School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology, Tianjin 300384, P. R. China
E-mail: ghhigher@hotmail.com, hgao@tjut.edu.cn

^b Department of Chemistry and Biochemistry, North Dakota State University, Fargo, ND 58108-6050, USA

Abstract

A multifunctional photodynamic therapy (PDT) nanoplatform, characterized by red-shifted absorption and emission, was fabricated using an UiO-66-based metal–organic framework (MOF), a biscyclometalated iridium(III) complex, and a pH/ROS-responsive polycationic polymer. Noticeably, this promising nanoplatform exhibited good biocompatibility in the dark and produced abundant ROS upon light irradiation, which could achieve apparent endo/lysosome escape and kill cancer cells effectively.

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Article information

DOI: https://doi.org/10.1039/C9CC09357E
Article type: Communication
Submitted: 02 Dec 2019
Accepted: 09 Dec 2019
First published: 09 Dec 2019

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Chem. Commun., 2020,56, 762-765

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Construction of an iridium(III)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging

Y. Zhang, H. Fu, S. Chen, B. Liu, W. Sun and H. Gao, Chem. Commun., 2020, 56, 762 DOI: 10.1039/C9CC09357E

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Chemical Communications

Construction of an iridium(iii)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging†

Abstract

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Construction of an iridium(III)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging

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