Issue 10, 2020

Acid promoted radical-chain difunctionalization of styrenes with stabilized radicals and (N,O)-nucleophiles

Abstract

A difunctionalization of alkenes through sequential addition of a radical and a nucleophile has been developed, which is suggested to proceed by a radical chain mechanism not requiring a catalyst. An electron transfer step to the oxidant benzoyl peroxide is facilitated by protonation with a strong acid.

Graphical abstract: Acid promoted radical-chain difunctionalization of styrenes with stabilized radicals and (N,O)-nucleophiles

Supplementary files

Article information

Article type
Communication
Submitted
02 Dec 2019
Accepted
07 Jan 2020
First published
07 Jan 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 1557-1560

Acid promoted radical-chain difunctionalization of styrenes with stabilized radicals and (N,O)-nucleophiles

S. Liu and M. Klussmann, Chem. Commun., 2020, 56, 1557 DOI: 10.1039/C9CC09369A

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