Issue 24, 2020
From the journal:

Chemical Communications

A ratiometric 19F MR-based method for the quantification of Ca2+ using responsive paramagnetic probes†

Giuseppe Gambino, ORCID logo a   Tanja Gambino, ORCID logo a   Rolf Pohmannb  and  Goran Angelovski ORCID logo *a  

* Corresponding authors

a MR Neuroimaging Agents, MPI for Biological Cybernetics, Tuebingen, Germany
E-mail: goran.angelovski@tuebingen.mpg.de

b High-Field Magnetic Resonance, MPI for Biological Cybernetics, Tuebingen, Germany

Abstract

We present a method for assessing the extracellular calcium concentration using 19F chemical shift imaging. Specifically, a custom made calcium-responsive and lanthanide-based 19F MRI probe that undergoes a strong and highly specific modulation of its signal upon coordination with calcium ions was developed and its performance is presented.

Graphical abstract: A ratiometric 19F MR-based method for the quantification of Ca2+ using responsive paramagnetic probes

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Article information

DOI
https://doi.org/10.1039/C9CC09977H
Article type
Communication
Submitted
25 Dec 2019
Accepted
25 Feb 2020
First published
25 Feb 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 3492-3495

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A ratiometric 19F MR-based method for the quantification of Ca2+ using responsive paramagnetic probes

G. Gambino, T. Gambino, R. Pohmann and G. Angelovski, Chem. Commun., 2020, 56, 3492 DOI: 10.1039/C9CC09977H

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