Issue 22, 2020

Chemoenzymatic, biomimetic total synthesis of (−)-rugulosin B, C and rugulin analogues and their biosynthetic implications

Abstract

Herein, we report the chemoenzymatic synthesis of a heterodimeric (−)-rugulosin B, homodimeric (−)-rugulosin C, and several rugulin analogues in three to four steps starting from anthraquinones. This work supports dimerization between variously substituted putative monomeric intermediates during the biosynthesis of naturally occurring (+)-rugulosin B and C.

Graphical abstract: Chemoenzymatic, biomimetic total synthesis of (−)-rugulosin B, C and rugulin analogues and their biosynthetic implications

Supplementary files

Article information

Article type
Communication
Submitted
16 Jan 2020
Accepted
13 Feb 2020
First published
13 Feb 2020

Chem. Commun., 2020,56, 3337-3340

Chemoenzymatic, biomimetic total synthesis of (−)-rugulosin B, C and rugulin analogues and their biosynthetic implications

A. Mondal, S. K. Singh, T. Manna and S. M. Husain, Chem. Commun., 2020, 56, 3337 DOI: 10.1039/D0CC00406E

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