The operation of DNA nanodevices is often limited by erroneous strand displacement. Here we demonstrate simple design principles that reduce such leakage by up to two orders of magnitude. Enhanced operational robustness against multiple spurious inputs was obtained by simply relocating toehold overhangs to external locations and strengthening adjacent G–C clamping.
A. Bader and S. L. Cockroft, Chem. Commun., 2020, 56, 5135 DOI: 10.1039/D0CC00882F
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