Issue 81, 2020
From the journal:

Chemical Communications

Assembly of polysubstituted chiral cyclopropylamines via highly enantioselective Cu-catalyzed three-component cyclopropene alkenylamination†

Yu Zhang,‡a   Yuan Li,‡b   Wei Zhou,c   Mengru Zhang,a   Qian Zhang,a   Ran Jia ORCID logo *b  and  Jinbo Zhao ORCID logo *ac  

* Corresponding authors

a Jilin Province Key Laboratory of Functional Organic Molecule Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun, P. R. China
E-mail: zhaojb100@nenu.edu.cn

b Institute of Theoretical Chemistry, Jilin University, Changchun 130023, P. R. China
E-mail: jiaran@jlu.edu.cn

c Department of Chemistry and Biology, Changchun University of Technology, Changchun 130012, P. R. China
E-mail: zhaojinbo@ccut.edu.cn

Abstract

Enabled by a commercial bisphosphine ligand, the Cu-catalyzed three-component cyclopropene alkenylamination with alkenyl organoboron reagent and hyroxyamine esters proceeds with exceptionally high enantioselectivity to deliver poly-substituted cis-1,2-alkenylcyclopropylamines that contain up to all three stereogenic centers on the cyclopropane.

Graphical abstract: Assembly of polysubstituted chiral cyclopropylamines via highly enantioselective Cu-catalyzed three-component cyclopropene alkenylamination

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0CC01060J
Article type
Communication
Submitted
10 Feb 2020
Accepted
08 Sep 2020
First published
08 Sep 2020

Chem. Commun., 2020,56, 12250-12253

Permissions

Request permissions

Assembly of polysubstituted chiral cyclopropylamines via highly enantioselective Cu-catalyzed three-component cyclopropene alkenylamination

Y. Zhang, Y. Li, W. Zhou, M. Zhang, Q. Zhang, R. Jia and J. Zhao, Chem. Commun., 2020, 56, 12250 DOI: 10.1039/D0CC01060J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements