Red light-triggered photoreduction on a nucleic acid template

Subrata Dutta; Jennifer Rühle; Margot Schikora; Nina Deussner-Helfmann; Mike Heilemann; Timofei Zatsepin; Patrick Duchstein; Dirk Zahn; Günther Knör; Andriy Mokhir

doi:10.1039/D0CC03086D

Red light-triggered photoreduction on a nucleic acid template†

Subrata Dutta,^a Jennifer Rühle,^a Margot Schikora,^a Nina Deussner-Helfmann,^b Mike Heilemann,

^b Timofei Zatsepin,

^cd Patrick Duchstein,

^e Dirk Zahn,

^e Günther Knör

^f and Andriy Mokhir

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry and Pharmacy, Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), 91058 Erlangen, Germany
E-mail: Andriy.Mokhir@fau.de

^b Institute of Physical and Theoretical Chemistry, Johann Wolfgang Goethe-University, 60438 Frankfurt, Germany

^c Skolkovo Institute of Science and Technology, Moscow, Russia

^d Chemistry Department, M. V. Lomonosov Moscow State University, Leninskie gory, 1-3, Moscow 119992, Russia

^e Computer-Chemistry-Center, Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany

^f Johannes Kepler University Linz, Institute of Inorganic Chemistry, Austria

Abstract

Conjugate Sn(IV)(pyropheophorbide a)dichloride–(peptide nucleic acid) catalyzes reduction of azobenzene derivatives in the presence of complementary nucleic acid (NA) upon irridiation with red light (660 nm). This is the first red light-induced NA-templated photoreduction. It is highly sensitive to single mismatches in the NA-template and can detect down to 5 nM NAs.

Chemical Communications

Red light-triggered photoreduction on a nucleic acid template†

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