Clustered nanobody–drug conjugates for targeted cancer therapy†
Abstract
A clustered Nb–drug conjugate (cNDC@PEG) was designed using anti-EGFR Nb to specifically deliver Pt(IV) prodrugs to tumors. cNDC@PEG efficiently targets EGFR positive tumor cells, and the clustered cNDC@PEG is more efficient in inhibiting tumor growth in vivo than the monomeric NDC. This work provides a novel strategy for the construction of a multi-valent NDC using dendrimers.