Issue 77, 2020
From the journal:

Chemical Communications

A chemical covalent tactic for bio-thiol sensing and protein labeling agent design†

Liangwei Zhang, ORCID logo *ab   Jie Kang,b   Shudi Liu,*c   Xia Zhang,a   Jinyu Sun,b   Yuesong Hu,b   Yang Yanga  and  Lingxin Chen ORCID logo *a  

* Corresponding authors

a CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
E-mail: liangweizhang@yic.ac.cn, lxchen@yic.ac.cn

b State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

c College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China
E-mail: liushd@lzu.edu.cn

Abstract

Discovering novel chemical reactions is important for bioanalysis. Herein, we report a tactic for bio-thiol sensing and protein labeling agent design by the installation of a sulfoxide group onto the skeleton of various fluorophores, and powerfully validate its abilities, which may shed light on the development of specific protein tags to give insight into their biological functions.

Graphical abstract: A chemical covalent tactic for bio-thiol sensing and protein labeling agent design

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Article information

DOI
https://doi.org/10.1039/D0CC04169F
Article type
Communication
Submitted
15 Jun 2020
Accepted
14 Aug 2020
First published
14 Aug 2020

Chem. Commun., 2020,56, 11485-11488

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A chemical covalent tactic for bio-thiol sensing and protein labeling agent design

L. Zhang, J. Kang, S. Liu, X. Zhang, J. Sun, Y. Hu, Y. Yang and L. Chen, Chem. Commun., 2020, 56, 11485 DOI: 10.1039/D0CC04169F

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