Construction of aptasensors for sensitive detection of 8-OH-dG based on a diffusion mediated electrochemiluminescence quenching effect

Zhe Feng; Rui-Juan Zhao; Ze-Hua Lu; Li-ping Jia; Rong-Na Ma; Wei Zhang; Lei Shang; Qing-Wang Xue; Huai-Sheng Wang

doi:10.1039/D0CC04492J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Construction of aptasensors for sensitive detection of 8-OH-dG based on a diffusion mediated electrochemiluminescence quenching effect†

Zhe Feng,^a Rui-Juan Zhao,^a Ze-Hua Lu,^b Li-ping Jia,

*^a Rong-Na Ma,^a Wei Zhang,^a Lei Shang,^a Qing-Wang Xue^a and Huai-Sheng Wang

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Liaocheng University, Liaocheng 252000, China
E-mail: jialiping@lcu.edu.cn, hswang@lcu.edu.cn

^b Liaocheng Veterans Hospital, Liaocheng 252000, China

Abstract

A DNA immobilization-free ECL aptasensor was developed for the detection of 8-hydroxy-2′-deoxygunosine based on the diffusion mediated ECL quenching effect. This ECL aptasensor exhibited a high sensitivity and low detection limit by combining homogeneous DNA reaction with dual signal amplifications: target-induced multi-DNA release and Exo I-assisted target recycling.

Download options Please wait...

Supplementary files

Supplementary information PDF (340K)

Article information

DOI: https://doi.org/10.1039/D0CC04492J
Article type: Communication
Submitted: 29 Jun 2020
Accepted: 08 Aug 2020
First published: 11 Aug 2020

Download Citation

Chem. Commun., 2020,56, 11074-11077

Permissions

Request permissions

Construction of aptasensors for sensitive detection of 8-OH-dG based on a diffusion mediated electrochemiluminescence quenching effect

Z. Feng, R. Zhao, Z. Lu, L. Jia, R. Ma, W. Zhang, L. Shang, Q. Xue and H. Wang, Chem. Commun., 2020, 56, 11074 DOI: 10.1039/D0CC04492J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Construction of aptasensors for sensitive detection of 8-OH-dG based on a diffusion mediated electrochemiluminescence quenching effect†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Construction of aptasensors for sensitive detection of 8-OH-dG based on a diffusion mediated electrochemiluminescence quenching effect

Social activity

Search articles by author

Spotlight

Advertisements