Issue 76, 2020

Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC

Abstract

We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.

Graphical abstract: Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC

Supplementary files

Article information

Article type
Communication
Submitted
15 Jul 2020
Accepted
29 Jul 2020
First published
29 Jul 2020

Chem. Commun., 2020,56, 11223-11226

Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC

Q. Xie, M. M. Wiedmann, A. Zhao, I. R. Pagan, R. P. Novick, H. Suga and T. W. Muir, Chem. Commun., 2020, 56, 11223 DOI: 10.1039/D0CC04873A

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