Spontaneous membrane-less multi-compartmentalization via aqueous two-phase separation in complex coacervate micro-droplets

Nicolette G. Moreau; Nicolas Martin; Pierangelo Gobbo; T.-Y. Dora Tang; Stephen Mann

doi:10.1039/D0CC05399F

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Spontaneous membrane-less multi-compartmentalization via aqueous two-phase separation in complex coacervate micro-droplets†

Nicolette G. Moreau,

^a Nicolas Martin,

^b Pierangelo Gobbo,

^a T.-Y. Dora Tang

^c and Stephen Mann

*^ade

Author affiliations

* Corresponding authors

^a Centre for Protolife Research and Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK
E-mail: s.mann@bristol.ac.uk

^b Univ. Bordeaux, CNRS, Centre de Recherche Paul Pascal, UMR5031, 115 Avenue du Dr Albert Schweitzer, 33600 Pessac, France

^c Max Planck Institute of Molecular Cell and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany

^d BrisSynBio Synthetic Biology Research Centre, Life Sciences Building, University of Bristol, Tyndall Avenue, Bristol, UK

^e Max Planck Bristol Centre for Minimal Biology, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK

Abstract

Polyelectrolyte/nucleotide multiphase complex coacervate droplets are produced by internalized aqueous two-phase separation and used for the spatially dependent chemical transfer of sugar molecules, providing a step towards the development of membrane-free “organelles” within coacervate-based protocells.

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DOI: https://doi.org/10.1039/D0CC05399F
Article type: Communication
Submitted: 10 Aug 2020
Accepted: 10 Sep 2020
First published: 10 Sep 2020
This article is Open Access

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Chem. Commun., 2020,56, 12717-12720

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Spontaneous membrane-less multi-compartmentalization via aqueous two-phase separation in complex coacervate micro-droplets

N. G. Moreau, N. Martin, P. Gobbo, T.-Y. D. Tang and S. Mann, Chem. Commun., 2020, 56, 12717 DOI: 10.1039/D0CC05399F

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Chemical Communications

Spontaneous membrane-less multi-compartmentalization via aqueous two-phase separation in complex coacervate micro-droplets†

Abstract

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Spontaneous membrane-less multi-compartmentalization via aqueous two-phase separation in complex coacervate micro-droplets

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