Issue 12, 2020
From the journal:

Chemical Society Reviews

Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives

Bruno Linclau, ORCID logo a   Ana Ardá, ORCID logo b   Niels-Christian Reichardt, ORCID logo c   Matthieu Sollogoub, ORCID logo d   Luca Unione, ORCID logo e   Stéphane P. Vincent ORCID logo f  and  Jesús Jiménez-Barbero ORCID logo *bgh  

* Corresponding authors

a School of Chemistry, University of Southampton, Highfield, Southampton SO171BJ, UK

b CIC bioGUNE, Basque Research and Technology Alliance (BRTA), 48160 Derio, Spain
E-mail: jjbarbero@cicbiogune.es

c CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Donostia-San Sebastian, Spain

d Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, UMR 8232, 4 place Jussieu, 75005 Paris, France

e Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Science, Utrecht University, Universiteitsweg 99, Utrecht, The Netherlands

f Department of Chemistry, Laboratory of Bio-organic Chemistry, University of Namur (UNamur), B-5000 Namur, Belgium

g Ikerbasque, Basque Foundation for Science, Maria Diaz de Haro 3, 48013 Bilbao, Spain

h Department of Organic Chemistry II, Faculty of Science and Technology, UPV/EHU, 48940 Leioa, Spain

Abstract

This review provides an extensive summary of the effects of carbohydrate fluorination with regard to changes in physical, chemical and biological properties with respect to regular saccharides. The specific structural, conformational, stability, reactivity and interaction features of fluorinated sugars are described, as well as their applications as probes and in chemical biology.

Graphical abstract: Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives

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Article information

DOI
https://doi.org/10.1039/C9CS00099B
Article type
Review Article
Submitted
30 Mar 2020
First published
10 Jun 2020
This article is Open Access
Creative Commons BY-NC license

Chem. Soc. Rev., 2020,49, 3863-3888

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Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives

B. Linclau, A. Ardá, N. Reichardt, M. Sollogoub, L. Unione, S. P. Vincent and J. Jiménez-Barbero, Chem. Soc. Rev., 2020, 49, 3863 DOI: 10.1039/C9CS00099B

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