Issue 5, 2020
From the journal:

Catalysis Science & Technology

Regioselective aromatic O-demethylation with an artificial P450BM3 peroxygenase system†

Yihui Jiang,‡ab   Chunlan Wang,‡a   Nana Ma,cd   Jie Chen,cd   Chuanfei Liu,c   Fang Wang,a   Jiakun Xu ORCID logo *a  and  Zhiqi Cong ORCID logo *cd  

* Corresponding authors

a Key Lab of Sustainable Development of Polar Fisheries, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Lab for Marine Drugs and Byproducts of Pilot National Lab for Marine Science and Technology, Qingdao 266071, China
E-mail: xujk@ysfri.ac.cn

b College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China

c CAS Key Laboratory of Biofuels and Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, China
E-mail: congzq@qibebt.ac.cn

d University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

Several simple single- and double-mutants of cytochrome P450BM3 enzymes enabled a highly regioselective O-demethylation of aromatic ethers with H2O2 with the assistance of a dual-functional small molecule (DFSM). The DFSM-facilitated P450BM3 peroxygenase system provides an alternative, simple approach for a key step in the bioconversion of lignin compared with reported NADPH-dependent P450 monooxygenases.

Graphical abstract: Regioselective aromatic O-demethylation with an artificial P450BM3 peroxygenase system

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Article information

DOI
https://doi.org/10.1039/D0CY00241K
Article type
Communication
Submitted
26 Dec 2019
Accepted
21 Feb 2020
First published
21 Feb 2020

Catal. Sci. Technol., 2020,10, 1219-1223

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Regioselective aromatic O-demethylation with an artificial P450BM3 peroxygenase system

Y. Jiang, C. Wang, N. Ma, J. Chen, C. Liu, F. Wang, J. Xu and Z. Cong, Catal. Sci. Technol., 2020, 10, 1219 DOI: 10.1039/D0CY00241K

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