Issue 21, 2020

Reduction of Taylor–Aris dispersion by lateral mixing for chromatographic applications

Abstract

Chromatographic columns are suffering from Taylor–Aris dispersion, especially for slowly diffusing molecules such as proteins. Since downscaling the channel size to reduce Taylor–Aris dispersion meets fundamental pressure limitations, new strategies are needed to further improve chromatography beyond its current limits. In this work we demonstrate a method to reduce Taylor–Aris dispersion by lateral mixing in a newly designed silicon AC-electroosmotic flow mixer. We obtained a reduction in κaris by a factor of three in a 40 μm × 20 μm microchannel, corresponding to a plate height gain of 2 to 3 under unretained conditions at low to high Pe values. We also demonstrate an improvement of a reverse-phase chromatographic separation of coumarins.

Graphical abstract: Reduction of Taylor–Aris dispersion by lateral mixing for chromatographic applications

Supplementary files

Article information

Article type
Paper
Submitted
30 Jul 2020
Accepted
22 Sep 2020
First published
22 Sep 2020

Lab Chip, 2020,20, 3938-3947

Reduction of Taylor–Aris dispersion by lateral mixing for chromatographic applications

E. Y. Westerbeek, J. G. Bomer, W. Olthuis, J. C. T. Eijkel and W. De Malsche, Lab Chip, 2020, 20, 3938 DOI: 10.1039/D0LC00773K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements